Current Brain Tumor Clinical Protocols
Originally published Spring 2002

Carolina Neurosurgery & Spine Associates, in cooperation with the Blumenthal Cancer Center at Carolinas Medical Center, is offering a number of clinical protocols for the treatment of patients with primary and metastatic brain tumors. A list of the available programs is provided below. For more information on how to submit a patient for participation in one of these trials, please contact Anthony Asher, M.D., F.A.C.S., or his research coordinator, Anthony Minichiello at 704-371-5130.

“A Phase III Randomized Trial of the Role of Whole Brain Radiation Therapy in Addition to Radiosurgery in the Management of Patients with One to Three Cerebral Metastases” Multi-Institutional, Cooperative NCI Trial Administered Through the American College of Surgeons Oncology Group

“A Phase II Study Utilizing the Gliasite Radiation Therapy System in the Treatment of Resected Solitary Brain Metastases,” Carolinas Medical Center

“Phase I Study of a Recombinant Chimeric Protein Composed of Circularly Permuted IL-4 and Mutated Form of the Pseudomonas Exotoxin Termed IL-4”

(38-37) – PE38KDEL for the Treatment of Recurrent Malignant Astrocytoma, Carolinas Medical Center

“Phase I Trial of Surgery Gliadel And Carboplatin in Combination With Radiation Therapy for Anaplastic Astrocytoma or Glioblastoma Multiforme” Carolinas Medical Center

“A Study to Evaluate Normal Brain Tissue Cells and Cancerous Brain Tissue Cells for the Expression of Interleukin-4 and Interleukin-13 Receptors,” Carolinas Medical Center

“Open label, Non-Randomized Multicenter Study of Interstitial 131I-chTNT-1/B for the Treatment of Newly Diagnosed or Recurrent Malignant Glioma,” Carolinas Medical Center

RTOG 94-02 “Pure or Mixed Anaplastic Oligodendroglioma. RT Alone vs. RT + PCV Chemotherapy. Phase III”

RTOG 98-02 “Low Grade Glioma. Favorable > Observation Unfavorable > RT +/- PCV”

SWOG S9811 “Unresectable meningioma. Hydroxyurea. Phase II”

SWOG E4397 “Adult Medulloblastoma, PNET, Ependymoma. Post Op Chemo > RT. Phase II”

RTOG BR-0013 “GBM. Conventional RT > Intratumoral Bleomycin. Phase II”

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© 2002 Carolina Neurosurgery & Spine Associates